Chromatin signaling in muscle stem cells: interpreting the regenerative microenvironment

Chromatin signaling in muscle stem cells: interpreting the regenerative microenvironment

Blog Article

Muscle regeneration in the adult occurs in response to damage at expenses of a population of adult stem cells, the satellite cells.Upon here injury, either physical or genetic, signals released within the satellite cell niche lead to the commitment, expansion and differentiation of the pool of muscle progenitors to repair damaged muscle.To achieve this goal satellite cells undergo a dramatic reprogramming of the genome to coordinately activate and repress specific subset of genes.

Although the epigenetics of muscle regeneration have been extensively discussed, less emphasis has been put on how extra-cellular cues are translated into the specific chromatin reorganization necessary for progression through the myogenic program.In this review we will focus on how satellite cells sense the regenerative microenvironment in physiological and pathological circumstances, paying particular attention to the chicago cubs earrings mechanism through which the external stimuli are transduced to the nucleus to modulate chromatin structure and gene expression.We will discuss the pathways involved and how alterations in this chromatin signaling may contribute to satellite cells dysfunction during aging and disease.